Work Packages

WP1. Rat Leydig cells: effects and mechanism of action of single and mixed EDCs on steroidogenesis during sexual development;

WP2. Human HepG2, rat H4IIE and fish ZFL hepatocytes: toxicity, proliferative/apoptotic actions of single EDCs and mixtures;

WP3. Aquatic organisms: effects of environmentally relevant concentrations of selected EDCs and mixtures on Daphnia magna reproduction and growth of Myriophyllum aquaticum in complex matrices of freshwater ecosystems;

WP4. Zebrafish: studies on xenobiotic metabolic pathways, with special focus on characterization of ecotoxicologically relevant phase II enzymes.